Non-coding RNAs and genome stability in budding yeast.
mardi 19 juin 2012 - 11:30-13:30
Institut Curie, UMR3244, 26, rue d"Ulm, Paris
Lieu : Salle de Conférences Pierre Schaeffer Bâtiment 409
Pervasive transcription is now accepted to be a general feature of eukaryotic genome, generating short, long or abortive transcripts, some cleaned by RNA surveillance pathways. If no systematic analyses have addressed the cellular function(s) of pervasive transcription yet, numerous examples of regulatory non-coding ncRNAs have been established to control gene expression and chromatin domain formation. In S. cerevisiae a broad range of large ncRNAs synthesized from intra- and inter-genic regions have been characterized. This seminar will focus on a novel class of Xrn1-sensitive unstable non-coding Transcripts (XUTs) and more particularly on the characterisation and function of non-coding RNAs produced form subtelomeric regions (subTERRA).
Contact : Olivier NAMY